CANCER RESEARCH

SCIENTIFIC RESEARCH PAPERS

BY FRANCO CAVALERI

HAIR FOLLICLE AND SKIN HEALTH

Study of Drug Target Identification and Associated Molecular Mechanisms for the Therapeutic Activity and Hair Follicle Induction of Two Ashwagandha Extracts Having Differential Withanolide Constitutions

Ashwagandha is a medicinal plant used in Indian medicine for many conditions. The root contains special compounds called withanolides, which are key to its effects. Researchers studied how different ways of extracting ashwagandha affect these withanolides. They found that the makeup of these withanolides changes how the extract works in cells. This suggests that for ashwagandha to be reliable as a medicine, researchers need to standardize how it's extracted, not just the amount of withanolides, but also the specific types present.

The 3 Curcuminoid Analogs Comprising the Curcumin Extract Comparably Inhibit Nuclear Factor kappa-light-chain-enhancer Activation

Curcumin supplements contain a mix of 3 curcuminoid molecules. Though similar, they might have different effects. This study examined these curcuminoids individually in cells. Surprisingly, all three acted the same way in inhibiting a cellular process. While researchers expected variation, this suggests similar effects for this process, but they'll investigate if these molecules differ when targeting other cellular functions.

Curcuminoid Analogs Differentially Modulate Nuclear Factor Kappa-Light-Chain-Enhancer, P65 Serine276, Mitogen- and Stress-activated Protein Kinase 1 And MicroRNA 148a Status

Curcumin supplements, despite success in treating inflammation, can vary in effectiveness. This is because they contain a mix of 3 slightly different molecules that each target different parts of a cell's inflammatory response. While some effects overlap, this research shows promise for using specific curcuminoids to target specific aspects of inflammation. Standardizing the mix of these molecules could improve the reliability of curcumin-based treatments.

Presenting a New Standard Drug Model for Turmeric and Its Prized Extract, Curcumin

Curcumin, the active ingredient in turmeric, shows promise for treating inflammation but suffers from unreliable results in studies. This might be because curcumin itself has complex effects and current research samples aren't standardized. The researchers propose a new way to analyze curcumin's effects and standardize the extract, which could lead to more reliable treatments.

The True Nature of Curcumin’s Polypharmacology

Curcumin, a concentrated extract from turmeric, is used for inflammation and other issues. While promising, studies show conflicting results. This might be because curcumin contains several slightly different molecules, each potentially having unique effects. Researchers propose these differences contribute to curcumin's broad range of effects and may explain some of the inconsistencies in research.

Study of Drug Targets Associated With Oncogenesis and Cancer Cell Survival and the Therapeutic Activity of Engineered Ashwagandha Extract Having Differential Withanolide Constitutions

Ashwagandha, known for its health benefits, is hard to use reliably in cancer treatment due to variations in its active ingredients. Researchers developed a consistent extract called Oncowithanib. When tested on breast cancer cells (MCF7), Oncowithanib reduced cell survival and growth, increased cell death, and suppressed key enzymes involved in cell survival. This suggests Oncowithanib could be a promising cancer treatment, but more research is needed. Standardizing herbal extracts is crucial for reliable therapeutic results.

Butyric Acid Influences How β-Hydroxybutyrate Modulates Fatty Acid Oxidation and Ketogenesis To Support Ketosis

The ketogenic diet is effective but hard to stick with. This research explores a supplement that combines BHB (a ketone) and BA (a fatty acid) to potentially help people reach ketosis (burning fat for energy) with a less restrictive diet. Early tests in cells show this supplement might increase fat burning and antioxidant activity. More research is needed, but this could be a way to make the keto diet easier and potentially more beneficial.

Potential Synergies of β -Hydroxybutyrate and Butyrate on the Modulation of Metabolism, Inflammation, Cognition, and General Health

The keto diet is popular for weight loss and treating some diseases, but it's strict and can cause side effects. This research review suggests adding ketone supplements might make it safer and easier to stick with. They found a specific ketone and fatty acid combo might be especially helpful, but more research is needed to understand exactly how it works.

NEURODEGENERATIVE DISEASE RESEARCH

Review of Amyotrophic Lateral Sclerosis, Parkinson’s and Alzheimer’s diseases helps further define proteomic events of the novel paradigm for Alzheimer’s with metals as primary disease cause

Although ALS, Parkinson's, and Alzheimer's appear distinct, they might share underlying causes. This research reviews how these diseases, despite different symptoms, may have similar genetic and cellular defects. The review also explores the potential role of heavy metals in Alzheimer's and how it might connect to the other diseases. This new perspective could help us understand these diseases better and develop new treatments.

Corrigendum to “Review of Amyotrophic Lateral Sclerosis, Parkinson’s and Alzheimer’s diseases helps further define proteomic events of the novel paradigm for Alzheimer’s with metals as primary disease cause” [Med. Hypotheses 85 (2015) 779–790]

Paradigm shift redefining molecular, metabolic and structural events in Alzheimer’s disease involves a proposed contribution by transition metals. Defined lengthy preclinical stage provides new hope to circumvent advancement of disease- and age-related neurodegeneration

Alzheimer's disease (AD) is often linked to heavy metal poisoning. This research proposes a new theory: instead of being harmful, the brain actually uses amyloid plaque, a hallmark of AD, to trap and remove these metals. The enzyme that creates amyloid plaque (BACE1) is usually seen as bad, but this theory suggests it's actually a protective mechanism. In healthy brains, this system can work for years, but eventually it gets overwhelmed by metal buildup and other factors, leading to the full-blown symptoms of AD.

Corrigendum to “Paradigm shift redefining molecular, metabolic and structural events in Alzheimer’s disease involves a proposed contribution by transition metals. Defined lengthy preclinical stage provides new hope to circumvent advancement of disease- and age-related neurodegeneration” [Med. Hypotheses 84 (2015) 460–469]